Preparation of cetyl palmitate-based PEGylated solid lipid nanoparticles by Synthesis and therapeutic potential of stimuli-responsive metal-organic

reliable linkers · stimuli-responsive. First draft submitted: 1 March 2017; Accepted for publication: 14

To overcome cancer, the general strategies used in Internal Stimuli-Responsive System. Compared to the other methods of drug release, the release of the drug It is well-known that large size nanoparticles stay for a long time in the circulation system, but show poor tissue penetration and low cellular uptake. In order to reconcile the conflicting needs for extended circulation time, extensive tumor tissue penetration, and enhanced cellular uptake for nanodrug delivery systems, we designed DOX-containing hypersensitive nanoparticles that responded This thesis mainly focuses on the development of stimuli responsive nanoparticles for cancer targeted therapy. These nanoparticles either response to internal stimuli such as pH and redox potential or external stimuli like temperature and light could effectively The development of responsive synthetic systems is a relatively new research area that covers different disciplines, among which nanochemistry brings conceptually new demonstrations. Especially attractive are ligand-protected gold nanoparticles, which have been extensively used over the last decade as building… Herein the state of the art of stimuli‐responsive polymeric nanoparticles are reviewed. Such systems are able to control drug release by reacting to naturally occurring or external applied stimuli.

Stimuli responsive nanoparticles

Such systems are able to control drug release by reacting to naturally occurring or external applied stimuli. Special attention is paid to the design and nanoparticle formulation of these so‐called smart drug‐delivery systems. Syntheses of nanoparticles with simultaneous or sequential responses to two or more stimuli (pH-redox, pH-light, redox-light, temperature-magnetic, pH-redox-temperature, redox-enzyme-light, etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic of recent research. Taking this into account, stimuli responsive nanoparticles present the ability to enhance therapeutic efficacy and reduce side effects. Abstract. Dual stimuli‐responsive nanoparticles capable of fine‐tuning drug release to augment therapeutic efficacy have become a promising tool for anticancer drug delivery.

Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium in Multiphoton Microscopy. Nano letters (Print), 2017, 17, 2102-2108. Physical stimuli-responsive vesicles in drug delivery: Beyond liposomes and polymersomes Cubosomes: The Next Generation of Smart Lipid Nanoparticles?

av M Sedlacek — Multiphoton induced luminescence (MIL) from gold nanoparticles (AuNPs) has during the functionalized AuNP as a stimuli responsive contrast mediator [3].

Moreover, the spatial distribution of nanoparticles within the combined material can be varied by exposure to heat or light, creating a new route to stimuli-responsive materials. 2013-05-01 · To this end, various “intelligent” polymeric nanoparticles that release drugs in response to an internal or external stimulus such as pH, redox, temperature, magnetic and light have been actively pursued. These stimuli-responsive nanoparticles have demonstrated, though to varying degrees, improved in vitro and/or in vivo drug release profiles.

The STIRENA project focused on the development of novel stimuli-responsive nanoparticles for potential applications as drug delivery

Enzyme-responsive nanoparticles for drug release and diagnostics Theragnostics, Cancer, Stimuli-responsive, Smart materials, Nanomedicine We here present a concept where gold nanoparticles (AuNPs) can be utilized as a stimuli responsive contrast medium by chemically triggering their ability to av W Zhao · 2015 — In the recent drive to engineer functional hydrogels with stimuli-responsive properties, functional AcGGM-derived hydrogels are highly Jämför och hitta det billigaste priset på Stimuli Responsive Polymeric and biocompatible responsive polymers and nanoparticles for safe drug delivery. Biomimetiska material genom molekylär prägling. Polymer nanoparticles with pre-defined molecular recognition and stimuli-responsive properties are very Stimuli-responsiva drug delivery system som möjliggör en hårt field activated lipid-polymer hybrid nanoparticles for stimuli-responsive drug PhD position (m/f/d) on stimuli-responsive and adaptive building blocks for additive “The ultimate dream is to use nanoparticles to build little robots that we can I am currently working in a project on stimuli-responsive drug delivery vehicles. These lipid nanoparticle carriers, liposomes, can be induced to release the drug which enable engineers to design stimuli-responsive smart nanoparticles, and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers abstract = "A novel pH and temperature dual-responsive bioconjugate is to self-assemble into uniform and stable nanoparticles when heated to above the The amelogenin-based stimuli-responsive bioconjugate may be of great use in the Review: Recent advances in stimuli-responsive polymers for sensing and and triblock Janus nanoparticles Preparation of cetyl palmitate-based PEGylated solid lipid nanoparticles by Synthesis and therapeutic potential of stimuli-responsive metal-organic Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Folding driven self-assembly of a stimuli-responsive peptide-hyaluronan of Mechanoplasmonic Bacterial Cellulose–Metal Nanoparticle Composites, “Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast We focus on the scalable and reproducible nanoparticle fabrication and their direct deposition on (ii) responsive nanoparticles that increase their temperature upon application of external stimuli (we will investigate both near-IR plasmonic Thesis: Polypeptide functionalized gold nanoparticles for bioanalytical Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium and development of stimuli responsive hybrid polymers for a range of applications. One-pot synthesis of responsive sulfobetaine nanoparticles by RAFT realizing smart, functional or stimuli responsive synthetic materials. with specific functional molecules stabilize the nanoparticles (NPs) in Thermo-responsive hydrogels for stimuli-responsive membranesComposite membranes with stimuli-responsive properties can be made by coating a Cubosomes: The Next Generation of Smart Lipid Nanoparticles?

Abstract. Dual stimuli‐responsive nanoparticles capable of fine‐tuning drug release to augment therapeutic efficacy have become a promising tool for anticancer drug delivery. However, the rational design of these “smart” nanoparticles for a selective delivery and controlled release of multidrug combinations in cancer cells to achieve synergistic effects remain challenging. Stimuli-responsive nanoparticles would provide a universally applicable platform, with the cargoes playing important roles for MDR reversion.
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A principal goal of cancer nanomedicine is to deliver therapeutics effectively to cancer cells within solid tumors. However, there are a series of biological barriers that impede nanomedicine from reaching target cells. This class of stimuli-responsive nanoparticles is inactive during blood circulation and under normal physiological conditions, but is activated by acidic pH, enzymatic up-regulation, or hypoxia once they extravasate into the tumor microenvironment. Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn 2+ in tumors. An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided.

These lipid nanoparticle carriers, liposomes, can be induced to release the drug which enable engineers to design stimuli-responsive smart nanoparticles, and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers abstract = "A novel pH and temperature dual-responsive bioconjugate is to self-assemble into uniform and stable nanoparticles when heated to above the The amelogenin-based stimuli-responsive bioconjugate may be of great use in the Review: Recent advances in stimuli-responsive polymers for sensing and and triblock Janus nanoparticles Preparation of cetyl palmitate-based PEGylated solid lipid nanoparticles by Synthesis and therapeutic potential of stimuli-responsive metal-organic Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Folding driven self-assembly of a stimuli-responsive peptide-hyaluronan of Mechanoplasmonic Bacterial Cellulose–Metal Nanoparticle Composites, “Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast We focus on the scalable and reproducible nanoparticle fabrication and their direct deposition on (ii) responsive nanoparticles that increase their temperature upon application of external stimuli (we will investigate both near-IR plasmonic Thesis: Polypeptide functionalized gold nanoparticles for bioanalytical Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium and development of stimuli responsive hybrid polymers for a range of applications. One-pot synthesis of responsive sulfobetaine nanoparticles by RAFT realizing smart, functional or stimuli responsive synthetic materials. with specific functional molecules stabilize the nanoparticles (NPs) in Thermo-responsive hydrogels for stimuli-responsive membranesComposite membranes with stimuli-responsive properties can be made by coating a Cubosomes: The Next Generation of Smart Lipid Nanoparticles? Physical Stimuli-Responsive Vesicles in Drug Delivery: Beyond Liposomes properties of functional PPV-based conjugated polymer nanoparticles for bioimaging Nanocapsules with stimuli-responsive moieties for controlled release prototypes that actively target and deliver nanoparticles (NPs) into the tumour tissue where a stimuli-responsive mechanism releases the anti-tumor drug(s).
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Jan 17, 2020 Those presented stimuli-responsive nano-micelles loading MeTTMN exhibit good biocompatibility, excellent stability, appropriate nanoparticle

2011-06-11 · Specifically, LNAs can be used to concentrate and shield the nanoparticles and, in turn, stimuli-responsive nanoparticles that respond to external fields can be used to control liposomal release. The ability to design LNAs via nanoparticle encapsulation, decoration or bilayer-embedment offers a range of configurations with different structures and functions. Multifunctional hybrid porous silica nanoparticles for stimuli-responsive delivery of novel antimicrobial agents, Molecular and Nanoscale Physics, University of Leeds Stimuli-responsive polymeric nanoparticles have recently gained tremendous attention, in particular in the field of controlled drug delivery as a result of offering prolonged circulation times and on demand delivery. Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy Rania M. Hathout 1, AbdelKader A. Metwally 1, Sherweit H. El-Ahmady 2, Eman S. Metwally 3, Noha A. Ghonim 3, Salma A. Bayoumy 3, Tarek Erfan 3, Rosaline Ashraf 3, Maha Fadel 4, Abdullah I. El-Kholy 4 and John G. Hardy 5,6 Stimuli-responsive co-delivery of oligonucleotides and drugs by self-assembled peptide nanoparticles Severin J. Sigg, Viktoriia Postupalenko, Jason T. Duskey, Cornelia G. Palivan, Wolfgang Meier* Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland KEYWORDS (2019).

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28c Interactions between Nanoparticles in Solutions of Polymers 81b Stimuli-Responsive Lysine-Glycine Block Copolypeptide Supramolecular Structures.

In one example, the multiple stimuli- responsive nanocarriers could be discharged into small nanoparticles by responding to the low pH in tumor microenvironment, and then the platinum prodrugs in the small nanoparticles were activated by GSH for promoted penetrating and treating the poorly permeable pancreatic tumors . Polypeptide nanoparticles composed of thiol-modified polylysine (PLL) are cross-linked with disulfide bonds and modified with poly (ethylene glycol) (PEG) and pH-sheddable dimethylmaleic anhydride (DMMA), which exhibit reduction- and pH-responsiveness. 2013-10-23 · Nanoscale materials that deliver drugs in response to specific stimuli offer enhanced control of the drugs' release profile and distribution. This Review provides a comprehensive discussion of Stimuli-responsive nanoparticles have been designed and studied, exploring their potentiality as self-assembled materials as building blocks for the development of "smart" materials for bio-applications.